HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, officially abbreviated HMGCR) is the rate-controlling enzyme (NADH-dependent, EC 1.1.1.88; NADPH-dependent, EC 1.1.1.34) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. Information on EC 1.1.1.34 - hydroxymethylglutaryl-CoA reductase (NADPH) EC 3.1.3.47 [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase. Hmg-coa reductase, 3-hydroxy-3-methylglutaryl coenzyme a reductase, hmgr, In enzymology, a hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) is an enzyme that catalyzes the chemical reaction. (R)-mevalonate + CoA + 2 HMG-CoA reductase is the rate-limiting enzyme for cholesterol (NADPH), HMG-CoA reductase, hydroxymethylglutaryl-CoA reductase hydroxymethylglutaryl-CoA reductase (NADPH); hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate);
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